For US Healthcare Professionals Only

Vaccine effectiveness in adults 50+: A DEVASTATING DISADVANTAGE11

In adults 50+

Decreased vaccine effectiveness supports the need for age-specific vaccines11

References: 1. Warren-Gash C, Blackburn R, Whitaker H, McMenamin J, Hayward AC. Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland. Eur Respir J. 2018;51. doi:10.1183/13993003.01794-2017. 2. Kwong JC, Schwartz KL, Campitelli MA, et al. Acute myocardial infarction after laboratory-confirmed influenza infection. N Engl J Med. 2018;378:345-353. 3. Kytömaa S, Hegde S, Claggett B, et al. Association of influenza-like illness activity with hospitalizations for heart failure: the Atherosclerosis Risk in Communities study. JAMA Cardiol. 2019;4:363-369. 4. Allard R, Leclerc P, Tremblay C, Tannenbaum T-N. Diabetes and the severity of pandemic influenza A (H1N1) infection. Diabetes Care. 2010;33:1491-1493. 5. Hulme KD, Gallo LA, Short KR. Influenza virus and glycemic variability in diabetes: a killer combination? Front Microbiol. 2017;8:861. 6. Wilking H, Buda S, von der Lippe E, et al. Mortality of 2009 pandemic influenza A(H1N1) in Germany. Euro Surveill. 2010;15. pii:19741. 7. National Foundation for Infectious Diseases. Call to action: the dangers of influenza and benefits of vaccination in adults with chronic health conditions. September 2018. https://www.nfid.org/wpcontent/uploads/2019/08/cta-dangers-of-influenza-in-adults-with-chronic-health-c.pdf. Accessed October 31, 2019. 8. Centers for Disease Control and Prevention. FluView. Laboratory-confirmed influenza hospitalizations. https://gis.cdc.gov/grasp/fluview/FluHospChars.html. Accessed November 22, 2019. 9. MacIntyre CR, Mahimbo A, Moa AM, Barnes M. Influenza vaccine as a coronary intervention for prevention of myocardial infarction. Heart. 2016;102:1953-1956. 10. Vamos EP, Pape UJ, Curcin V, et al. Effectiveness of the influenza vaccine in preventing admission to hospital and death in people with type 2 diabetes. CMAJ. 2016;188:E342-E351. 11. Flannery B, et al. Adjusted vaccine effectiveness against medically attended influenza by age group, US Flu VE Network, 2018–19. https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2019-06/flu-3-flannery-508.pdf. Accessed November 22, 2019.